Preferential organ attachment and invasion in vitro by B16 melanoma cells selected for differing metastatic colonization and invasive properties.

@article{Nicolson1985PreferentialOA,
  title={Preferential organ attachment and invasion in vitro by B16 melanoma cells selected for differing metastatic colonization and invasive properties.},
  author={Garth L. Nicolson and Kim M. Dulski and Craig Todd Basson and Danny R Welch},
  journal={Invasion & metastasis},
  year={1985},
  volume={5 3},
  pages={144-58}
}
Murine B16 melanoma sublines have been sequentially selected in vivo for low (B16-F1) or high (B16-F10) lung, high ovary (B16-O10) or high brain (B16-B15b) colonization, and in vitro for enhanced tissue invasion (B16-BL6). These B16 sublines were tested in vitro in a syngeneic organ adhesion/invasion assay to determine differences in tumor and/or host tissue properties that might account for preferential metastasis to certain sites. Tissues used were murine C57BL/6 lung, ovary and heart. In 8… CONTINUE READING

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