Preferential motor unit loss in the SOD1 G93A transgenic mouse model of amyotrophic lateral sclerosis.

@article{Hegedus2008PreferentialMU,
  title={Preferential motor unit loss in the SOD1 G93A transgenic mouse model of amyotrophic lateral sclerosis.},
  author={Janka Hegedus and Charles T. Putman and Neil Tyreman and Tessa Gordon},
  journal={The Journal of physiology},
  year={2008},
  volume={586 14},
  pages={3337-51}
}
The present study investigated motor unit (MU) loss in a murine model of familial amyotrophic lateral sclerosis (ALS). The fast-twitch tibialis anterior (TA) and medial gastrocnemius (MG) muscles of transgenic SOD1(G93A) and SOD1(WT) mice were studied during the presymptomatic phase of disease progression at 60 days of age. Whole muscle maximum isometric twitch and tetanic forces were 80% lower (P < 0.01) in the TA muscles of SOD1(G93A) compared to SOD1(WT) mice. Enumeration of total MU numbers… CONTINUE READING
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