Preferential methylation of unmethylated DNA by Mammalian de novo DNA methyltransferase Dnmt3a.

@article{Yokochi2002PreferentialMO,
  title={Preferential methylation of unmethylated DNA by Mammalian de novo DNA methyltransferase Dnmt3a.},
  author={Tomoki Yokochi and Keith D. Robertson},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 14},
  pages={11735-45}
}
DNA methylation is an epigenetic modification of DNA. There are currently three catalytically active mammalian DNA methyltransferases, DNMT1, -3a, and -3b. DNMT1 has been shown to have a preference for hemimethylated DNA and has therefore been termed the maintenance methyltransferase. Although previous studies on DNMT3a and -3b revealed that they act as functional enzymes during development, there is little biochemical evidence about how new methylation patterns are established and maintained… CONTINUE READING