Preferential metabolism by macrophages of conditioned rabbit hypercholesterolemic remnant lipoproteins.

@article{Haratz1988PreferentialMB,
  title={Preferential metabolism by macrophages of conditioned rabbit hypercholesterolemic remnant lipoproteins.},
  author={D Haratz and Olga Stein and Rosi Shwartz and Elliot M Berry and Yechezkiel Stein},
  journal={Biochimica et biophysica acta},
  year={1988},
  volume={959 2},
  pages={
          127-33
        }
}
Rabbits were fed a diet containing 1% cholesterol, and lipoproteins were isolated from their plasma by sequential ultracentrifugation. Lipoprotein remnants (d = 1.019-1.063) were conditioned by incubation with bovine aortic smooth muscle cells for 24 h and then incubated for 4 h with J774 cells or mouse peritoneal macrophages. Conditioning of remnants and low-density lipoproteins resulted in enhancement of their uptake and metabolism by the macrophages in culture. The macrophages metabolized… CONTINUE READING

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