Preferential labeling of inhibitory and excitatory cortical neurons by endogenous tropism of adeno-associated virus and lentivirus vectors.

@article{Nathanson2009PreferentialLO,
  title={Preferential labeling of inhibitory and excitatory cortical neurons by endogenous tropism of adeno-associated virus and lentivirus vectors.},
  author={Jason Lawrence Nathanson and Yuchio Yanagawa and Kunihiko Obata and Edward M. Callaway},
  journal={Neuroscience},
  year={2009},
  volume={161 2},
  pages={441-50}
}
Despite increasingly widespread use of recombinant adeno-associated virus (AAV) and lentiviral (LV) vectors for transduction of neurons in a wide range of brain structures and species, the diversity of cell types within a given brain structure is rarely considered. For example, the ability of a vector to transduce neurons within a brain structure is often assumed to indicate that all neuron types within the structure are transduced. We have characterized the transduction of mouse somatosensory… CONTINUE READING
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