Preferential integration of human papillomavirus type 18 near the c-myc locus in cervical carcinoma

  title={Preferential integration of human papillomavirus type 18 near the c-myc locus in cervical carcinoma},
  author={Matthew J. Ferber and Erik C. Thorland and Antoinette A. T. P. Brink and Anton K Rapp and L. A. Phillips and Renee M. McGovern and Bobbie S. Gostout and Tak Hong Cheung and Tong Kwok Hung Chung and Wong Yick Fu and David I. Smith},
The development of cervical cancer is highly associated with human papillomavirus (HPV) infection. Greater than 99% of all cervical tumors contain HPV DNA. Integration of high-risk HPV has been temporally associated with the acquisition of a malignant phenotype. Recent work from our lab has shown that HPV16, the most common high-risk HPV associated with cervical carcinoma, preferentially integrates at loci containing human common fragile sites (CFSs). CFSs are regions of genomic instability… CONTINUE READING


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