Preferential incorporation of sn-2 lysoPC DHA over unesterified DHA in the young rat brain.

@article{This1994PreferentialIO,
  title={Preferential incorporation of sn-2 lysoPC DHA over unesterified DHA in the young rat brain.},
  author={Frank Thi{\`e}s and C Pillon and Patrick Moli{\`e}re and Michel Lagarde and Jean Lecerf},
  journal={The American journal of physiology},
  year={1994},
  volume={267 5 Pt 2},
  pages={R1273-9}
}
The uptake and metabolism of [3H]docosahexaenoic acid (DHA) esterified at the sn-2 position of lysophosphatidylcholine (lysoPC DHA) and in the unesterified form, both bound to albumin, was studied in 20-day-old rats. LysoPC DHA was preferentially recovered in the brain (4-5% of the injected radioactivity) over the unesterified form of DHA (0.3-0.4%). Conversely, the lysoPC form was taken up less than or at the same extent as the unesterified form by the liver, heart, and kidney. In the brain… CONTINUE READING

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