Preferential expression of AChR epsilon-subunit in thymomas from patients with myasthenia gravis.

@article{MacLennan2008PreferentialEO,
  title={Preferential expression of AChR epsilon-subunit in thymomas from patients with myasthenia gravis.},
  author={Calman A MacLennan and Angela Vincent and Alexander Marx and Nicholas Willcox and Nils Eric Gilhus and John Newsom-Davis and David Beeson},
  journal={Journal of neuroimmunology},
  year={2008},
  volume={201-202},
  pages={28-32}
}
The role of antigen expression by thymomas in myasthenia gravis (MG) is not clear. Previous reports of acetylcholine receptor (AChR) mRNA expression by the highly sensitive reverse transcription-polymerase chain reactions (RT-PCR) produced varying results. To try to clarify this issue, we first used RT-PCR but then turned to the more accurate and quantitative RNase protection assays (RPA) to assess AChR subunit mRNA expression in thymomas from 25 patients (22 with MG). By RT-PCR, all five AChR… CONTINUE READING
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