Preferential expression and immunogenicity of HIV-1 Tat fusion protein expressed in tomato plant

Abstract

HIV-1 Tat plays a major role in viral replication and is essential for AIDS development making it an ideal vaccine target providing that both humoral and cellular immune responses are induced. Plant-based antigen production, due to its cheaper cost, appears ideal for vaccine production. In this study, we created a plant-optimized tat and mutant (Cys30Ala… (More)
DOI: 10.1007/s11248-009-9358-9

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4 Figures and Tables