Preferential elevation of Prx I and Trx expression in lung cancer cells following hypoxia and in human lung cancer tissues

@article{Kim2003PreferentialEO,
  title={Preferential elevation of Prx I and Trx expression in lung cancer cells following hypoxia and in human lung cancer tissues},
  author={Hyo Jung Kim and H.-Z. Chae and Y. H. Kim and T.-S. Hwang and E.-M. Park and Y.-M. Park},
  journal={Cell Biology and Toxicology},
  year={2003},
  volume={19},
  pages={285-298}
}
Transient/chronic microenvironmental hypoxia that exists within a majority of solid tumors has been suggested to have a profound influence on tumor growth and therapeutic outcome. Since the functions of novel antioxidant proteins, peroxiredoxin I (Prx I) and II, have been implicated in regulating cell proliferation, differentiation, and apoptosis, it was of our special interest to probe a possible role of Prx I and II in the context of hypoxic tumor microenvironment. Since both Prx I and II use… CONTINUE READING
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