Preferential effects of caffeine on limbic and cortical dopamine systems.

@article{Stoner1988PreferentialEO,
  title={Preferential effects of caffeine on limbic and cortical dopamine systems.},
  author={Gene R. Stoner and Lana R. Skirboll and S L Werkman and Daniel W. Hommer},
  journal={Biological psychiatry},
  year={1988},
  volume={23 8},
  pages={761-8}
}
In this study, we investigated the effects of acute caffeine administration on the activity of midbrain dopamine neurons. Caffeine significantly depressed the firing rates of dopamine neurons in the ventral tegmental area (A10 group), but had no significant effect on the firing rates of dopamine neurons in the substantia nigra zona compacta (A9 group). The action of caffeine in A10 was completely blocked by pretreatment with the adenosine agonist L-phenyl-isopropyl-adenosine (L-PIA), confirming… CONTINUE READING

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