Preferential digestion of basement membrane collagen by an enzyme derived from a metastatic murine tumor.

@article{Liotta1979PreferentialDO,
  title={Preferential digestion of basement membrane collagen by an enzyme derived from a metastatic murine tumor.},
  author={Lance A. Liotta and Shoko Abe and Pamela Robey and Gail R. Martin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1979},
  volume={76 5},
  pages={2268-72}
}
The specificity of human skin collagenase and of an enzyme from an invasive tumor were studied by using types I, II, III, IV, and V (AB) collagen as substrates. Human skin collagenase degraded types I, II, and III collagen, producing the characteristic 3/4 and 1/4 cleavage products, but failed to degrade type IV or V collagen. Collagenase prepared from the invasive tumors showed maximal activity after trypsin treatment. The tumor enzyme degraded type IV (basement membrane) collagen, producing… CONTINUE READING

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