Preferential deimination of keratin K1 and filaggrin during the terminal differentiation of human epidermis.

@article{Senshu1996PreferentialDO,
  title={Preferential deimination of keratin K1 and filaggrin during the terminal differentiation of human epidermis.},
  author={Tatsuo Senshu and Sidney Chunping Kan and Hideoki Ogawa and Motomu Manabe and Hiroaki Asaga},
  journal={Biochemical and biophysical research communications},
  year={1996},
  volume={225 3},
  pages={
          712-9
        }
}
The upper layers of mammalian epidermis contain citrulline-containing proteins formed by enzymatic deimination of arginine residues. To study the role of protein deimination in epidermal differentiation, we identified deiminated proteins extracted from human epidermis. Major deiminated proteins were identified as partially degraded keratin K1, while those from keratin K10 and a highly heterogeneous mixture of deiminated filaggrin isomers were detected as minor components. Deiminated keratins… CONTINUE READING
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