Preferential cytotoxicity of the type I ribosome inactivating protein alpha-momorcharin on human nasopharyngeal carcinoma cells under normoxia and hypoxia.

@article{Pan2014PreferentialCO,
  title={Preferential cytotoxicity of the type I ribosome inactivating protein alpha-momorcharin on human nasopharyngeal carcinoma cells under normoxia and hypoxia.},
  author={Wen Liang Pan and Jack Ho Wong and Evandro Fei Fang and Yau Sang Chan and T. H. B. Ng and Randy Chi Fai Cheung},
  journal={Biochemical pharmacology},
  year={2014},
  volume={89 3},
  pages={329-39}
}
All primary nasopharyngeal carcinoma (NPC) tumors contain hypoxic regions which are implicated in decreased local control and increased distant metastases, as well as resistance to chemotherapy in advanced NPC patients. One of the promising therapeutic approaches for NPC is to use drugs that can target hypoxic factors in tumors. In the present investigation, the type I ribosome inactivating protein α-momorcharin (α-MMC), isolated from seeds of the bitter gourd Momordica charantia, reduced cell… CONTINUE READING
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