Preferential costimulation by CD80 results in IL-10-dependent TGF-beta1(+) -adaptive regulatory T cell generation.

@article{Prez2008PreferentialCB,
  title={Preferential costimulation by CD80 results in IL-10-dependent TGF-beta1(+) -adaptive regulatory T cell generation.},
  author={Nicol{\'a}s P{\'e}rez and Subha Karumuthil-Melethil and Ruobing Li and Bellur S Prabhakar and Mark J. Holterman and Chenthamarakshan Vasu},
  journal={Journal of immunology},
  year={2008},
  volume={180 10},
  pages={6566-76}
}
Costimulatory ligands CD80 and CD86 have different binding preferences and affinities to their receptors, CD28 and CTLA-4. Earlier, we demonstrated that CD80 binds to CTLA-4 with higher affinity and has a role in suppressing T cell response. The current study demonstrates that not only did blockade of CD86 upon Ag presentation by bone marrow-derived dendritic cells (DC) to OVA-specific T cells result in induction of hyporesponsive T cells but also that these T cells could suppress the… CONTINUE READING

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