Preferential cell death of CD8+ effector memory (CCR7-CD45RA-) T cells by hydrogen peroxide-induced oxidative stress.

@article{Takahashi2005PreferentialCD,
  title={Preferential cell death of CD8+ effector memory (CCR7-CD45RA-) T cells by hydrogen peroxide-induced oxidative stress.},
  author={Akihiro Takahashi and Mikael G. V. Hanson and H{\aa}kan R. Norell and Aleksandra Mandic Havelka and Koji Kono and K J Malmberg and Rolf V. R. Kiessling},
  journal={Journal of immunology},
  year={2005},
  volume={174 10},
  pages={6080-7}
}
T cells are used in many cell-based cancer treatments. However, oxidative stress that is induced during various chronic inflammatory conditions, such as cancer, can impair the immune system and have detrimental effects on T cell function. In this study, we have investigated the sensitivity of different human T cell subsets to H(2)O(2)-induced oxidative stress. We showed that central memory (CD45RA(-)CCR7(+)) and effector memory (CD45RA(-)CCR7(-)) T cells are more sensitive to H(2)O(2) as… CONTINUE READING
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