Preferential block of small myelinated sensory and motor fibers by lidocaine: in vivo electrophysiology in the rat sciatic nerve.

@article{Gokin2001PreferentialBO,
  title={Preferential block of small myelinated sensory and motor fibers by lidocaine: in vivo electrophysiology in the rat sciatic nerve.},
  author={Alex P Gokin and Bridget Philip and Gary R. Strichartz},
  journal={Anesthesiology},
  year={2001},
  volume={95 6},
  pages={1441-54}
}
BACKGROUND Controversy still surrounds the differential susceptibility of nerve fibers to local anesthetics and its relation to selective functional deficits. In the current study we report features of conduction blockade in different classes of rat sciatic nerve fibers after injection of lidocaine by a percutaneous procedure that closely resembles clinical applications. METHODS In 30 adult male Sprague-Dawley rats (weight, 300-400 g) during general anesthesia, impulses were recorded in… CONTINUE READING
27 Citations
49 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 27 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 49 references

Afterpotentials in nonmyelinated nerve fibers

  • R Jirounek, PC Chardonnens Em Brunet
  • J Neurophysiol
  • 1991
1 Excerpt

Similar Papers

Loading similar papers…