Corpus ID: 22295171

Preferential binding of copper to the beta domain of metallothionein.

  title={Preferential binding of copper to the beta domain of metallothionein.},
  author={K. B. Nielson and D. Winge},
  journal={The Journal of biological chemistry},
  volume={259 8},
  • K. B. Nielson, D. Winge
  • Published 1984
  • Chemistry, Medicine
  • The Journal of biological chemistry
  • Proteolytic studies of rat liver metallothionein reconstituted in vitro with Cu salts revealed that the 2 metal centers fill in an ordered fashion. The B cluster in the NH2-terminal beta domain fills prior to Cu binding in cluster A. This is in contradistinction to cluster formation induced by the binding of Cd or Zn ions in which cluster A is the center of initial binding. The formation of metal cluster B by Cu occurs in a cooperative fashion yielding a saturated cluster with approximately 6… CONTINUE READING
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