Preferential binding of copper to the beta domain of metallothionein.

@article{Nielson1984PreferentialBO,
  title={Preferential binding of copper to the beta domain of metallothionein.},
  author={K B Nielson and Dennis R Winge},
  journal={The Journal of biological chemistry},
  year={1984},
  volume={259 8},
  pages={4941-6}
}
Proteolytic studies of rat liver metallothionein reconstituted in vitro with Cu salts revealed that the 2 metal centers fill in an ordered fashion. The B cluster in the NH2-terminal beta domain fills prior to Cu binding in cluster A. This is in contradistinction to cluster formation induced by the binding of Cd or Zn ions in which cluster A is the center of initial binding. The formation of metal cluster B by Cu occurs in a cooperative fashion yielding a saturated cluster with approximately 6… CONTINUE READING

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Metal Ions in Biological Systems (Sigel, H., ed

  • M. Vasak, J.H.R. Kagi
  • 1983

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