Preferential amplification of the paternal allele of the N–myc gene in human neuroblastomas

@article{Cheng1993PreferentialAO,
  title={Preferential amplification of the paternal allele of the N–myc gene in human neuroblastomas},
  author={Judy M. Cheng and J. Hiemstra and S. S. Schneider and A. Naumova and N. Cheung and S. Cohn and L. Diller and C. Sapienza and G. Brodeur},
  journal={Nature Genetics},
  year={1993},
  volume={4},
  pages={191-194}
}
Genomic imprinting plays a role in influencing the parental origin of genes involved in cancer–specific rearrangements. We have analysed 22 neuroblastomas with N–myc amplification to determine the parental origin of the amplified N–myc allele and the allele that is deleted from chromosome 1p. We analysed DNA from neuroblastoma patients and their parents, using four polymorphisms for 1 p and three for the N–myc amplicon. We determined that the paternal allele of N–myc was preferentially… Expand
Analysis of genomic imprinting at 1p35-36 in neuroblastoma.
Chromosome bands 1p35–36 contain two distinct neuroblastoma tumor suppressor loci, one of which is imprinted
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AMPLIFIED ALLELE OF THE HUMAN N‐myc ONCOGENE IN NEUROBLASTOMAS
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