Preferential activation of CD4+V beta 5.2/5.3+ intestinal intraepithelial lymphocytes in the inflamed lesions of Crohn's disease.

@article{Watanabe1996PreferentialAO,
  title={Preferential activation of CD4+V beta 5.2/5.3+ intestinal intraepithelial lymphocytes in the inflamed lesions of Crohn's disease.},
  author={Masaaki Watanabe and Akihiro Hayashi and Yasuo Hosoda and Masahiro {\^O}hara and Yasushi Iwao and Hiromasa Ashitani Noriaki Ishii and Hiroki Ishikawa and Masanobu Nanno and Toshifumi Hibi},
  journal={Clinical immunology and immunopathology},
  year={1996},
  volume={78 2},
  pages={130-9}
}
To analyze the nature of intestinal intraepithelial lymphocytes (iIELs) in inflammatory intestinal disease, we established T cell lines of iIELs isolated from endoscopic biopsied ileal and colonic mucosa of Crohn's disease patients. Seven T cell lines from the inflamed terminal ileum of 13 patients, but none of 16 T cell lines from normal terminal ileum, have shown a deviation of T cell receptor variable region gene usage and were enriched in the proportion of CD4+V beta 5.2/5.3+ cells. CD4+V… CONTINUE READING