Preferential accessibility of the yeast his3 promoter is determined by a general property of the DNA sequence, not by specific elements.

@article{Mai2000PreferentialAO,
  title={Preferential accessibility of the yeast his3 promoter is determined by a general property of the DNA sequence, not by specific elements.},
  author={Xiao-li Mai and Song Chou and Kevin Struhl},
  journal={Molecular and cellular biology},
  year={2000},
  volume={20 18},
  pages={6668-76}
}
Yeast promoter regions are often more accessible to nuclear proteins than are nonpromoter regions. As assayed by HinfI endonuclease cleavage in living yeast cells, HinfI sites located in the promoters of all seven genes tested were 5- to 20-fold more accessible than sites in adjacent nonpromoter regions. HinfI hypersensitivity within the his3 promoter region is locally determined, since it was observed when this region was translocated to the middle of the ade2 structural gene. Detailed… CONTINUE READING

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