Preferential Th 1 Immune Response in Invariant Chain-Deficient Mice 1

Abstract

MHC class II molecules associate with the invariant chain (Ii) molecule during biosynthesis. Ii facilitates the folding of class II molecules, interferes with their peptide association, and is involved in MHC class II transport. In this study, we have investigated the in vitro and in vivo immune response of Ii-deficient mice (Ii / ). Our results have… (More)

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