Preferential HLA usage in the influenza virus-specific CTL response.

  title={Preferential HLA usage in the influenza virus-specific CTL response.},
  author={Adrianus C M Boon and Gerrie de Mutsert and Ron A M Fouchier and Kees Sintnicolaas and Albert D M E Osterhaus and G F Rimmelzwaan},
  journal={Journal of immunology},
  volume={172 7},
To study whether individual HLA class I alleles are used preferentially or equally in human virus-specific CTL responses, the contribution of individual HLA-A and -B alleles to the human influenza virus-specific CTL response was investigated. To this end, PBMC were obtained from three groups of HLA-A and -B identical blood donors and stimulated with influenza virus. In the virus-specific CD8(+) T cell population, the proportion of IFN-gamma- and TNF-alpha-producing cells, restricted by… CONTINUE READING
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