Preferential Coupling of the NAADP Pathway to Exocytosis in T-Cells.

  title={Preferential Coupling of the NAADP Pathway to Exocytosis in T-Cells.},
  author={Lianne C. Davis and Frances M Platt and Antony Galione},
  volume={4 1},
A cytotoxic T-lymphocyte (CTL) kills an infected or tumorigenic cell by Ca2+-dependent exocytosis of cytolytic granules at the immunological synapse formed between the two cells. However, these granules are more than reservoirs of secretory cytolytic proteins but may also serve as unique Ca2+ signaling hubs that autonomously generate their own signals for exocytosis. This review discusses a selective role for the Ca2+-mobilizing messenger, nicotinic acid adenine dinucleotide phosphate (NAADP… CONTINUE READING


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