Preferential Accumulation of Antigen-specific Effector CD4 T Cells at an Antigen Injection Site Involves CD62E-dependent Migration but Not Local Proliferation

@article{Reinhardt2003PreferentialAO,
  title={Preferential Accumulation of Antigen-specific Effector CD4 T Cells at an Antigen Injection Site Involves CD62E-dependent Migration but Not Local Proliferation},
  author={R Lee Reinhardt and Daniel C. Bullard and Casey T Weaver and Marc K Jenkins},
  journal={The Journal of Experimental Medicine},
  year={2003},
  volume={197},
  pages={751 - 762}
}
The migration of antigen-specific T cells to nonlymphoid tissues is thought to be important for the elimination of foreign antigens from the body. However, recent results showing the migration of activated T cells into many nonlymphoid tissues raised the possibility that antigen-specific T cells do not migrate preferentially to nonlymphoid tissues containing antigen. We addressed this question by tracking antigen-specific CD4 T cells in the whole body after a localized subcutaneous antigen… CONTINUE READING

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