Preferences of transmembrane helices for cooperative amplification of Gαs and Gαq signaling of the thyrotropin receptor

@article{Jaeschke2008PreferencesOT,
  title={Preferences of transmembrane helices for cooperative amplification of Gαs and Gαq signaling of the thyrotropin receptor},
  author={Holger Jaeschke and Gunnar Kleinau and Jana Sontheimer and Sandra Mara Torres M{\"u}ller and Gerd Krause and Ralf Paschke},
  journal={Cellular and Molecular Life Sciences},
  year={2008},
  volume={65},
  pages={4028-4038}
}
Abstract.The majority of constitutively activating mutations (CAMs) of the thyroid-stimulating hormone receptor display a partially activated receptor. Thus, full receptor activation requires a multiplex activation process. To define impacts of different transmembrane helices (TMHs) on cooperative signal transduction, we combined single CAMs in particular TMHs to double mutations and measured second messenger accumulation of the Gαs and the Gαq pathway. We observed a synergistic increase for… CONTINUE READING
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