Preexisting pancreatic acinar cells contribute to acinar cell, but not islet beta cell, regeneration.

@article{Desai2007PreexistingPA,
  title={Preexisting pancreatic acinar cells contribute to acinar cell, but not islet beta cell, regeneration.},
  author={Biva M Desai and Jennifer M Oliver-Krasinski and Diva D De Le{\'o}n and Cyrus Farzad and Nankang Hong and Steven D. Leach and Doris A. Stoffers},
  journal={The Journal of clinical investigation},
  year={2007},
  volume={117 4},
  pages={971-7}
}
It has been suggested that pancreatic acinar cells can serve as progenitors for pancreatic islets, a concept with substantial implications for therapeutic efforts to increase insulin-producing beta cell mass in patients with diabetes. We report what we believe to be the first in vivo lineage tracing approach to determine the plasticity potential of pancreatic acinar cells. We developed an acinar cell-specific inducible Cre recombinase transgenic mouse, which, when mated with a reporter strain… CONTINUE READING
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