Preexisting lymphatic endothelium but not endothelial progenitor cells are essential for tumor lymphangiogenesis and lymphatic metastasis.

@article{He2004PreexistingLE,
  title={Preexisting lymphatic endothelium but not endothelial progenitor cells are essential for tumor lymphangiogenesis and lymphatic metastasis.},
  author={Yulong He and Iiro A Rajantie and Maritta Ilmonen and Taija Makinen and Marika J. Karkkainen and Paula Haiko and Petri Salv{\'e}n and Kari Alitalo},
  journal={Cancer research},
  year={2004},
  volume={64 11},
  pages={3737-40}
}
Endothelial progenitor cells have been shown to contribute to angiogenesis in various tumor models. Here, we have studied the relative contributions of bone marrow (BM)-derived endothelial progenitors and pre-existing lymphatic vessels to tumor lymphangiogenesis. We did not find significant incorporation of genetically marked BM-derived cells in lymphatic vessels during tumor- or vascular endothelial growth factor C-induced lymphangiogenesis. The degree of tumor lymphangiogenesis correlated… CONTINUE READING