Preexisting Serum Autoantibodies Against the NMDAR Subunit NR1 Modulate Evolution of Lesion Size in Acute Ischemic Stroke.

  title={Preexisting Serum Autoantibodies Against the NMDAR Subunit NR1 Modulate Evolution of Lesion Size in Acute Ischemic Stroke.},
  author={Maria Zerche and Karin Weissenborn and Christoph Ott and E. G{\"o}zde Dere and Abdul R Asif and Hans Worthmann and Imam Hassouna and Kristin Rentzsch and Anita Blanka Tryc and Liane Dahm and Johann Steiner and Lutz Binder and Jens Wiltfang and A. L. Sir{\'e}n and Winfried Stoecker and Hannelore Ehrenreich},
  volume={46 5},
BACKGROUND AND PURPOSE Recently, we reported high seroprevalence (age-dependent up to >19%) of N-methyl-d-aspartate-receptor subunit NR1 (NMDAR1) autoantibodies in both healthy and neuropsychiatrically ill subjects (N=4236). Neuropsychiatric syndrome relevance was restricted to individuals with compromised blood-brain barrier, for example, apolipoprotein E4 (APOE4) carrier status, both clinically and experimentally. We now hypothesized that these autoantibodies may upon stroke be protective in… CONTINUE READING
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