Preemptive liver transplantation in a child with familial hypercholesterolemia.

  title={Preemptive liver transplantation in a child with familial hypercholesterolemia.},
  author={Arianna Maiorana and Valerio Nobili and Sebastiano Calandra and Paola Francalanci and Silvia M Bernabei and May El Hachem and Lidia Monti and Fabrizio Gennari and Giuliano Torre and Jean de Ville de Goyet and Andrea Bartuli},
  journal={Pediatric transplantation},
  volume={15 2},
Familial hypercholesterolemia is an autosomal codominant disorder associated with markedly elevated plasma concentration of LDL-cholesterol and increased cardiovascular risk. Homozygous patients have rapid development of atherosclerosis with death from cardiovascular disease even in childhood. Life-long recurrent apheresis to reduce plasma LDL-cholesterol is considered the gold standard for treatment. Liver transplantation can be curative for this condition, but is usually only considered after… CONTINUE READING