Preemptive Activation of the Integrated Stress Response Protects Mice From Diet-Induced Obesity and Insulin Resistance by Fibroblast Growth Factor 21 Induction.

@article{Xu2018PreemptiveAO,
  title={Preemptive Activation of the Integrated Stress Response Protects Mice From Diet-Induced Obesity and Insulin Resistance by Fibroblast Growth Factor 21 Induction.},
  author={Xu Xu and Christopher Steven Krumm and Jae-Seon So and Curtis J Bare and Corey D Holman and Jesper Gromada and David E. Cohen and Ann-Hwee Lee},
  journal={Hepatology},
  year={2018},
  volume={68 6},
  pages={
          2167-2181
        }
}
Integrated stress response (ISR) is a signaling system in which phosphorylation of eukaryotic translation initiation factor 2α (eIF2α) by stress-specific kinases and subsequent activation of activation transcription factor (ATF) 4 help restore cellular homeostasis following exposure to environmental stresses. ISR activation has been observed in metabolic diseases, including hepatic steatosis (HS), steatohepatitis (SH), and insulin resistance (IR), but it remains unclear whether ISR contributes… CONTINUE READING
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