Preeclampsia is associated with alterations in DNA methylation of genes involved in collagen metabolism.

@article{Mousa2012PreeclampsiaIA,
  title={Preeclampsia is associated with alterations in DNA methylation of genes involved in collagen metabolism.},
  author={Ahmad Amine Mousa and Renato E Cappello and Guadalupe Estrada-Gutierrez and Juhi Shukla and Roberto Romero and Jerome F Strauss and Scott W. Walsh},
  journal={The American journal of pathology},
  year={2012},
  volume={181 4},
  pages={1455-63}
}
Maternal vascular dysfunction is a hallmark of preeclampsia. A recently described vascular phenotype of preeclampsia involves increased expression of matrix metalloproteinase-1 (MMP-1) in endothelial cells, vascular smooth muscle, and infiltrating neutrophils. In contrast, the expression of tissue inhibitor of metalloproteinases-1 (TIMP-1) and collagen type Iα 1 is either reduced or not changed in the vessels, suggesting an imbalance in vessel collagen degradation and synthesis in preeclampsia… CONTINUE READING

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