Preeclampsia and Fetal Congenital Heart Defects: Spurious Association or Maternal Confounding?

  title={Preeclampsia and Fetal Congenital Heart Defects: Spurious Association or Maternal Confounding?},
  author={B. Thilaganathan},
  • B. Thilaganathan
  • Published 2017
  • Medicine
  • Circulation
  • Article, see p 39 Human placentation is uniquely associated with physiological remodeling of the maternal spiral arteries by the invading trophoblast to produce a low-resistance maternal uterine circulation. The current paradigm considers defective placentation as the cause of preeclampsia, especially the preterm variety of the disorder.1 Related persistence of a high-resistance maternal uterine circulation, impaired placental perfusion, and maternal antiangiogenic stress response are all… CONTINUE READING
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