Preeclampsia: 2-methoxyestradiol induces cytotrophoblast invasion and vascular development specifically under hypoxic conditions.

@article{Lee2010Preeclampsia2I,
  title={Preeclampsia: 2-methoxyestradiol induces cytotrophoblast invasion and vascular development specifically under hypoxic conditions.},
  author={Soo Bong Lee and Amy P. Wong and Keizo Kanasaki and Yong Xu and Vivek K. Shenoy and Thomas F Mcelrath and George M. Whitesides and Raghu Kalluri},
  journal={The American journal of pathology},
  year={2010},
  volume={176 2},
  pages={710-20}
}
Inadequate invasion of the uterus by cytotrophoblasts is speculated to result in pregnancy-induced disorders such as preeclampsia. However, the molecular mechanisms that govern appropriate invasion of cytotrophoblasts are unknown. Here, we demonstrate that under low-oxygen conditions (2.5% oxygen), 2-methoxyestradiol (2-ME), which is a metabolite of estradiol and is generated by catechol-o-methyltransferase (COMT), induces invasion of cytotrophoblasts into a naturally-derived, extracellular… CONTINUE READING

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