Predominately glucocorticoid agonist actions of RU-486 in young specific-pathogen-free Zucker rats.

@article{Havel1996PredominatelyGA,
  title={Predominately glucocorticoid agonist actions of RU-486 in young specific-pathogen-free Zucker rats.},
  author={P. Havel and Bonnie L. Busch and Donald L. Curry and P. R. Johnson and Mary F. Dallman and Judith S. Stern},
  journal={The American journal of physiology},
  year={1996},
  volume={271 3 Pt 2},
  pages={R710-7}
}
Previous studies have demonstrated antiglucocorticoid actions for the progesterone receptor antagonist RU-486. In one study, daily administration of this drug for 2 wk decreased food intake (FI) and body weight gain (delta BW) in obese, but not lean, conventionally housed 5-wk-old female Zucker rats. We recently found that 2-wk administration of RU-486 attenuated delta BW in lean but not obese 12-wk-old male Zucker rats without affecting FI. To examine the actions of RU-486 and its effects on… CONTINUE READING