Predominant role of type 1 IP3 receptor in aortic vascular muscle contraction.

@article{Zhou2008PredominantRO,
  title={Predominant role of type 1 IP3 receptor in aortic vascular muscle contraction.},
  author={Hong Zhou and Takeshi Nakamura and Nagisa Matsumoto and Chihiro Hisatsune and Akihiro Mizutani and Takafumi Iesaki and Hiroyuki Daida and Katsuhiko Mikoshiba},
  journal={Biochemical and biophysical research communications},
  year={2008},
  volume={369 1},
  pages={213-9}
}
Inositol 1,4,5-trisphosphate receptor (IP(3)R) plays a crucial role in generating Ca(2+) signaling and three subtypes of IP(3)R have been identified. In spite of a high degree of similarity among these subtypes, their effects on spatio-temporal Ca(2+) patterns are specific and diverse; therefore the physiological significance of the differential expression levels of IP(3)R subtypes in various tissues remains unknown. Here, we examined the relative contribution of the specific subtype of IP(3)Rs… CONTINUE READING