Predominant role of tumor necrosis factor-alpha in human monocyte IL-10 synthesis.

  title={Predominant role of tumor necrosis factor-alpha in human monocyte IL-10 synthesis.},
  author={C Wanidworanun and Warren Strober},
  journal={Journal of immunology},
  volume={151 12},
In previous studies it has been shown that the bacterial endotoxin LPS induces an initial burst of inflammatory cytokine synthesis in human monocytes, which is followed by substantial IL-10 production; the IL-10 then down-regulates the inflammatory cytokine production as well as IL-10 production itself. Herein we tested the hypothesis that IL-10 production in human monocytes is under control of one of the cytokines induced by LPS. Accordingly, we cocultured purified human peripheral blood… CONTINUE READING


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