Predominant patterns of splicing evolution on human, chimpanzee and macaque evolutionary lineages.

@article{Xiong2018PredominantPO,
  title={Predominant patterns of splicing evolution on human, chimpanzee and macaque evolutionary lineages.},
  author={Jieyi Xiong and Xi Jiang and Angeliki Ditsiou and Yang Gao and Jing Sun and Elijah D Lowenstein and Shuyun Huang and Philipp Khaitovich},
  journal={Human molecular genetics},
  year={2018},
  volume={27 8},
  pages={1474-1485}
}
Although splicing is widespread and evolves rapidly among species, the mechanisms driving this evolution, as well as its functional implications, are not yet fully understood. We analyzed the evolution of splicing patterns based on transcriptome data from five tissues of humans, chimpanzees, rhesus macaques and mice. In total, 1526 exons and exon sets from 1236 genes showed significant splicing differences among primates. More than 60% of these differences represent constitutive-to-alternative… CONTINUE READING
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topGO: Enrichment Analysis for Gene Ontology., R package version 2.28.0. https:// bioconductor.org/packages/release/bioc/html/topGO.html

  • A. Alexa, J. Rahnenfuhrer
  • Human Molecular Genetics, 2018,
  • 2016
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