Predominant mode of human immunodeficiency virus transfer between T cells is mediated by sustained Env-dependent neutralization-resistant virological synapses.

@article{Chen2007PredominantMO,
  title={Predominant mode of human immunodeficiency virus transfer between T cells is mediated by sustained Env-dependent neutralization-resistant virological synapses.},
  author={Ping Chen and Wolfgang H{\"u}bner and Matthew Spinelli and Benjamin K Chen},
  journal={Journal of virology},
  year={2007},
  volume={81 22},
  pages={12582-95}
}
Cell-free human immunodeficiency virus type 1 (HIV-1) can initiate infections, but contact between infected and uninfected T cells can enhance viral spread through intercellular structures called virological synapses (VS). The relative contribution of VS to cell-free viral transfer has not been carefully measured. Using an ultrasensitive, fluorescent virus transfer assay, we estimate that when VS between HIV-expressing Jurkat T cells and primary CD4(+) T cells are formed, cell-associated… CONTINUE READING
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