Predominant integrin ligands expressed by osteoblasts show preferential regulation in response to both cell adhesion and mechanical perturbation.

@article{Carvalho2002PredominantIL,
  title={Predominant integrin ligands expressed by osteoblasts show preferential regulation in response to both cell adhesion and mechanical perturbation.},
  author={Roberto S. Carvalho and A Bumann and Jonathan L. Schaffer and Louis Charles Gerstenfeld},
  journal={Journal of cellular biochemistry},
  year={2002},
  volume={84 3},
  pages={497-508}
}
Previous studies have demonstrated that both mechanical perturbation and cell adhesion induced the expression of osteopontin (opn) by osteoblasts (Carvalho et al. [1998] J. Cell. Biochem. 70:376-390). The present study examined if these same stimuli on osteoblasts would induce the expression of other integrin binding proteins, specifically fibronectin (fn) and bone sialoprotein (bsp). All three genes showed three- to four-fold maximal induction in response to both cell adhesion and a single 2-h… CONTINUE READING

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