Predominant inhibition of interleukin-6 synthesis in patient-specific endothelial cells by mTOR inhibitors below a concentration range where cell proliferation is affected and mitotic arrest takes place.

@article{Lehle2005PredominantIO,
  title={Predominant inhibition of interleukin-6 synthesis in patient-specific endothelial cells by mTOR inhibitors below a concentration range where cell proliferation is affected and mitotic arrest takes place.},
  author={Karla Lehle and D E Dietrich E Birnbaum and J G J{\"u}rgen G Preuner},
  journal={Transplantation proceedings},
  year={2005},
  volume={37 1},
  pages={159-61}
}
UNLABELLED Organ rejection and inflammation are accompanied by endothelial cell activation. An in vitro model with patient-specific endothelial cells was used to study the impact of mTOR inhibitors on cell growth and release of proinflammatory cytokines. MATERIAL AND METHODS Confluent monolayers of human saphenous vein endothelial cells were pretreated with everolimus or sirolimus followed by induction with tumour necrosis factor-alpha (TNF-alpha). RESULTS Incubation with sirolimus or… CONTINUE READING

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