Predominant infiltration of macrophages and CD8(+) T Cells in cancer nests is a significant predictor of survival in stage IV nonsmall cell lung cancer.

@article{Kawai2008PredominantIO,
  title={Predominant infiltration of macrophages and CD8(+) T Cells in cancer nests is a significant predictor of survival in stage IV nonsmall cell lung cancer.},
  author={Osamu Kawai and Genichiro Ishii and Kaoru Kubota and Yukinori Murata and Yoichi Naito and Tetsuya Mizuno and K. Aokage and Nagahiro Saijo and Yutaka Nishiwaki and Akihiko Gemma and Syoji Kudoh and Atsushi Ochiai},
  journal={Cancer},
  year={2008},
  volume={113 6},
  pages={
          1387-95
        }
}
BACKGROUND The purpose of this study was to investigate whether tumor-infiltrating immune cells in biopsy specimens can be used to predict the clinical outcome of stage IV nonsmall cell lung cancer (NSCLC) patients. METHOD The authors performed an immunohistochemical study to identify and count the number of CD68(+) macrophages, c-kit(+) mast cells, and CD8(+) T cells in both cancer nests and cancer stroma in pretreatment biopsy specimens obtained from 199 patients with stage IV NSCLC treated… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 43 REFERENCES

Concurrent infiltration by CD81 T cells and CD41 T cells is a favorable prognostic factor in nonsmall-cell lung carcinoma

K Hiraoka, M Miyamoto, Y Cho
  • Br J Cancer
  • 2006
VIEW 1 EXCERPT

Macrophage and mast-cell invasion of tumor cell islets confers a marked survival advantage in non-small-cell lung cancer.

  • Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 2005
VIEW 1 EXCERPT

Tumor-associated macrophages: the double-edged sword in cancer progression.

  • Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 2005
VIEW 1 EXCERPT