Predominant hematopoietic origin of cell-free DNA in plasma and serum after sex-mismatched bone marrow transplantation.

@article{Lui2002PredominantHO,
  title={Predominant hematopoietic origin of cell-free DNA in plasma and serum after sex-mismatched bone marrow transplantation.},
  author={Yanni Yan-Ni Lui and Ki-wai Chik and Rossa W. K. Chiu and Chung-ho. Ho and C. K. Lam and Yuk Ming Dennis Lo},
  journal={Clinical chemistry},
  year={2002},
  volume={48 3},
  pages={
          421-7
        }
}
BACKGROUND Despite current interest in the biology and diagnostic applications of cell-free DNA in plasma and serum, the cellular origin of this DNA is poorly understood. We used a sex-mismatched bone marrow transplantation model to study the relative contribution of hematopoietic and nonhematopoietic cells to circulating DNA. METHODS We studied 22 sex-mismatched bone marrow transplantation patients. Paired buffy coat and plasma samples were obtained from all 22 patients. Matching serum… CONTINUE READING

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