Predominant expression of B7-H1 and its immunoregulatory roles in oral squamous cell carcinoma.

@article{Tsushima2006PredominantEO,
  title={Predominant expression of B7-H1 and its immunoregulatory roles in oral squamous cell carcinoma.},
  author={Fumihiko Tsushima and Kae Tanaka and Noriko Otsuki and Pornpan Youngnak and Hideyuki Iwai and Ken Omura and Miyuki Azuma},
  journal={Oral oncology},
  year={2006},
  volume={42 3},
  pages={268-74}
}
We examined cell surface expression of five B7 costimulatory molecules (B7-H1, B7-DC, B7h, CD80 and CD86) in human oral squamous cell carcinoma (SCC) lines. Most human SCC cell lines expressed various levels of B7-H1 and B7-DC. Their expression was further upregulated by interferon (IFN)-gamma stimulation. Immunohistochemical staining revealed substantial and predominant expression of B7-H1 on human primary oral SCC. A murine SCC line, NR-S1, neither expressed B7-H1 nor B7-DC, but induced B7-H1… CONTINUE READING