Predominant expression and activation-induced tyrosine phosphorylation of phospholipase C-gamma 2 in B lymphocytes.

@article{Coggeshall1992PredominantEA,
  title={Predominant expression and activation-induced tyrosine phosphorylation of phospholipase C-gamma 2 in B lymphocytes.},
  author={K Mark Coggeshall and Jimmy McHugh and Amnon Altman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1992},
  volume={89 12},
  pages={
          5660-4
        }
}
The triggering of T- or B-cell antigen-specific receptors is accompanied by rapid tyrosine phosphorylation of distinct cellular substrates, one of which is the gamma 1 isoform of inositol phospholipid-specific phospholipase C (PLC-gamma 1). This phosphorylation event, mediated by a putative protein tyrosine kinase coupled to the antigen receptor, probably stimulates the enzymatic activity of PLC-gamma 1, thereby promoting inositol phospholipid hydrolysis and other downstream signal transduction… CONTINUE READING

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