Predominant deposition of amyloid-beta 42(43) in plaques in cases of Alzheimer's disease and hereditary cerebral hemorrhage associated with mutations in the amyloid precursor protein gene.

@article{Mann1996PredominantDO,
  title={Predominant deposition of amyloid-beta 42(43) in plaques in cases of Alzheimer's disease and hereditary cerebral hemorrhage associated with mutations in the amyloid precursor protein gene.},
  author={David M A Mann and Takeshi Iwatsubo and Yasuo Ihara and Nigel J. Cairns and Peter L. Lantos and Nenad Bogdanovi{\'c} and Lars Lannfelt and Bengt Winblad and Marion L. C. Maat-Schieman and Martin Rossor},
  journal={The American journal of pathology},
  year={1996},
  volume={148 4},
  pages={1257-66}
}
Amyloid (A beta) deposition was investigated in cases of Alzheimer's disease and hereditary cerebral hemorrhage with amyloidosis, Dutch type, due to mutations in the amyloid precursor protein (APP) gene using the end-specific monoclonal antibodies BA27 and BC05 that recognize A beta 40 or A beta 42(43), respectively. In cases of APP717 mutation the predominant A beta species within plaques terminate at A beta 42(43) with relatively little A beta 40 being present. The total amount of A beta… CONTINUE READING

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
57 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 57 extracted citations

Similar Papers

Loading similar papers…