Predominant Role for Directly Transfected Dendritic Cells in Antigen Presentation to CD8+ T Cells after Gene Gun Immunization

@article{Porgador1998PredominantRF,
  title={Predominant Role for Directly Transfected Dendritic Cells in Antigen Presentation to CD8+ T Cells after Gene Gun Immunization },
  author={Angel Porgador and Kari R. Irvine and Akiko Iwasaki and Brian H. Barber and Nicholas P Restifo and Ronald N. Germain},
  journal={The Journal of Experimental Medicine},
  year={1998},
  volume={188},
  pages={1075 - 1082}
}
Cutaneous gene (DNA) bombardment results in substantial expression of the encoded antigen in the epidermal layer as well as detectable expression in dendritic cells (DC) in draining lymph nodes (LNs). Under these conditions, two possible modes of DC antigen presentation to naive CD8+ T cells might exist: (a) presentation directly by gene-transfected DC trafficking to local lymph nodes, and (b) cross-presentation by untransfected DC of antigen released from or associated with transfected… CONTINUE READING
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Enrichment of dendritic cells by plastic adherence and EA rosetting

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