Predominant HLA-class II bound self-peptides of a hematopoietic progenitor cell line are derived from intracellular proteins.


Human myeloid progenitor cells temporarily express HLA class II molecules during the differentiation pathway to granulocytes and macrophages. The significance of major histocompatibility complex (MHC) class II molecules at this stage of development is unknown. As a first stop of inquiry into their function, we have characterized the profile of major self… (More)


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