Predominant Autoantibody Production by Early Human B Cell Precursors

@article{Wardemann2003PredominantAP,
  title={Predominant Autoantibody Production by Early Human B Cell Precursors},
  author={Hedda Wardemann and Sergey Yurasov and Anne Schaefer and James W. Young and Eric Meffre and Michel C. Nussenzweig},
  journal={Science},
  year={2003},
  volume={301},
  pages={1374 - 1377}
}
During B lymphocyte development, antibodies are assembled by random gene segment reassortment to produce a vast number of specificities. A potential disadvantage of this process is that some of the antibodies produced are self-reactive. We determined the prevalence of self-reactive antibody formation and its regulation in human B cells. A majority (55 to 75%) of all antibodies expressed by early immature B cells displayed self-reactivity, including polyreactive and anti-nuclear specificities… 

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