Predominance of hepatitis B virus YMDD mutants is prognostic of viral DNA breakthrough.

@article{Lee2006PredominanceOH,
  title={Predominance of hepatitis B virus YMDD mutants is prognostic of viral DNA breakthrough.},
  author={Chang Hong Lee and S Kim and Kwan Soo Byun and Myung Soon Moon and Eun-Ok Kim and Jong Eun Yeon and Wangdon Yoo and Sun Pyo Hong},
  journal={Gastroenterology},
  year={2006},
  volume={130 4},
  pages={1144-52}
}
BACKGROUND & AIMS Hepatitis B virus (HBV) tyrosine, methionine, aspartate, aspartate (YMDD) mutants with or without additional compensatory mutations occur in chronically infected patients during lamivudine therapy and may be associated with accompanying viral breakthrough. The aim of this study was to determine whether a predominance of YMDD mutants could be a prognostic marker for occurrence of viral DNA breakthrough. METHODS YMDD genotypes in 740 consecutive samples collected from 116… CONTINUE READING

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Dynamics and early diagnosis of HBV resistance to lamivudine : a thorough quasispecies analysis

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